My experience with Healthspan has been pivotal because everyone listens and wants to help…and being on HRT has changed my life.
Bi-Est 50/50 Cream
Topical cream combining two bio-identical estrogens, Estradiol and Estriol, delivered through the skin. It relieves common peri- and menopause symptoms. Prescriptions require a hormone lab review and clinician consultation through our membership program.
Replenishes estrogen levels to help reduce hot flashes, night sweats, and dryness while improving tissue elasticity.
Balances neurotransmitters and cortisol to ease anxiety, sharpen focus, and improve sleep quality.
Helps prevent bone loss while supporting cardiovascular health through improved circulation and reduced inflammation.
Doctor prescribed. Dispensed by a LegitScript-certified pharmacy. Customized for you.
Starting at
99
$
/mo
Comprehensive Care
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Healthspan Care Philosophy
Bi-Est 50/50 Cream
Your body begins to respond within weeks and benefits build over time
Behind every symptom you feel is a biological process we help rebalance
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Frequently asked questions
Bi-Est 50/50 is a bio-identical estrogen cream containing a balanced blend of estradiol (E2) and estriol (E3). It’s designed to relieve menopause-related symptoms such as hot flashes, night sweats, mood changes, and vaginal dryness while supporting overall hormonal balance.
This compounded cream delivers estrogen directly through the skin, allowing for steady absorption and symptom relief. Estradiol provides stronger estrogenic activity, while estriol offers gentler support for vaginal and skin tissue health, making the blend both effective and well-tolerated.
Apply the cream once daily to clean, dry skin on the inner thigh, forearm, or abdomen. Rotate application sites and avoid skin-to-skin contact until fully absorbed. If your uterus is intact, your clinician will recommend pairing Bi-Est with progesterone for balance and safety.
Many women begin to feel improvements in hot flashes, sleep, or mood within one to two weeks after using Bi-Est 50/50 cream. Full benefits—including more consistent symptom relief and improved skin or vaginal tissue health—often develop over three months of consistent use
Mild breast tenderness or spotting may occur as hormone levels adjust. Less common effects include headaches or nausea. To prevent estrogen dominance symptoms, therapy should remain balanced with progesterone and monitored by your clinician.
When prescribed and monitored by licensed clinicians, bioidentical estrogen therapy is considered safe and effective for symptom relief in midlife. Healthspan includes lab testing, follow-up care, and personalized dosing to minimize risks and ensure optimal results.
The Women’s Health Program includes hormone lab testing, a clinician consultation, lifestyle coaching, and a personalized care plan. If hormone therapy is recommended, medication is billed separately at cost—so you only pay for what you need.
Bi-Est 50/50 is a bio-identical estrogen cream containing a balanced blend of estradiol (E2) and estriol (E3). It’s designed to relieve menopause-related symptoms such as hot flashes, night sweats, mood changes, and vaginal dryness while supporting overall hormonal balance.
This compounded cream delivers estrogen directly through the skin, allowing for steady absorption and symptom relief. Estradiol provides stronger estrogenic activity, while estriol offers gentler support for vaginal and skin tissue health, making the blend both effective and well-tolerated.
Apply the cream once daily to clean, dry skin on the inner thigh, forearm, or abdomen. Rotate application sites and avoid skin-to-skin contact until fully absorbed. If your uterus is intact, your clinician will recommend pairing Bi-Est with progesterone for balance and safety.
Many women begin to feel improvements in hot flashes, sleep, or mood within one to two weeks after using Bi-Est 50/50 cream. Full benefits—including more consistent symptom relief and improved skin or vaginal tissue health—often develop over three months of consistent use
Mild breast tenderness or spotting may occur as hormone levels adjust. Less common effects include headaches or nausea. To prevent estrogen dominance symptoms, therapy should remain balanced with progesterone and monitored by your clinician.
When prescribed and monitored by licensed clinicians, bioidentical estrogen therapy is considered safe and effective for symptom relief in midlife. Healthspan includes lab testing, follow-up care, and personalized dosing to minimize risks and ensure optimal results.
The Women’s Health Program includes hormone lab testing, a clinician consultation, lifestyle coaching, and a personalized care plan. If hormone therapy is recommended, medication is billed separately at cost—so you only pay for what you need.
