My experience with Healthspan has been pivotal because everyone listens and wants to help…and being on HRT has changed my life.
Bi-Est 50/50 Cream
Topical cream combining two bio-identical estrogens, Estradiol and Estriol, delivered through the skin. It relieves common peri- and menopause symptoms. Requires a baseline lab and clinical consultation, both included in the price of the medication.
Replenishes estrogen levels to help reduce hot flashes, night sweats, and dryness while improving tissue elasticity.
Balances neurotransmitters and cortisol to ease anxiety, sharpen focus, and improve sleep quality.
Helps prevent bone loss while maintaining cardiovascular, metabolic and brain health over time.
Includes clinical evaluation, baseline lab, medication, and ongoing dose adjustments
$
80
/mo
Healthspan Patients Get More
Expert-guided HRT, personalized with hormone lab insights
Baseline hormone panel to asses root causes
Customized treatment plans based on your data
Regular symptom tracking to see progress
Ongoing optimization and dosing adjustments
Behind every symptom you feel is a biological process we help rebalance
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4.9
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Effective treatments and excellent service earns us loyal support.
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Frequently asked questions
Bi-Est 50/50 is a bio-identical estrogen cream containing a balanced blend of estradiol (E2) and estriol (E3). It’s designed to relieve menopause-related symptoms such as hot flashes, night sweats, mood changes, and vaginal dryness while supporting overall hormonal balance.
This compounded cream delivers estrogen directly through the skin, allowing for steady absorption and symptom relief. Estradiol provides stronger estrogenic activity, while estriol offers gentler support for vaginal and skin tissue health, making the blend both effective and well-tolerated.
Apply the cream once daily to clean, dry skin on the inner thigh, forearm, or abdomen. Rotate application sites and avoid skin-to-skin contact until fully absorbed. If your uterus is intact, your clinician will recommend pairing Bi-Est with progesterone for balance and safety.
Many women begin to feel improvements in hot flashes, sleep, or mood within one to two weeks after using Bi-Est 50/50 cream. Full benefits—including more consistent symptom relief and improved skin or vaginal tissue health—often develop over three months of consistent use
Mild breast tenderness or spotting may occur as hormone levels adjust. Less common effects include headaches or nausea. To prevent estrogen dominance symptoms, therapy should remain balanced with progesterone and monitored by your clinician.
The medication includes an initial consultation with a licensed clinician, a free baseline hormone lab, a personalized treatment plan, regular check-ins to track progress, plus the Bi-Est 50/50 Cream. We offer HRT in 3-month treatment cycles to ensure safe, effective dose adjustments and proper clinical monitoring. The 3 month cost for Bi-Est 50/50 Cream is $239 which is equivalent to $80/month. If you are ineligible for treatment, you will be refunded the cost of the medication. Follow up labs may be necessary as part of your care plan and are charged separately.
Bi-Est 50/50 is a bio-identical estrogen cream containing a balanced blend of estradiol (E2) and estriol (E3). It’s designed to relieve menopause-related symptoms such as hot flashes, night sweats, mood changes, and vaginal dryness while supporting overall hormonal balance.
This compounded cream delivers estrogen directly through the skin, allowing for steady absorption and symptom relief. Estradiol provides stronger estrogenic activity, while estriol offers gentler support for vaginal and skin tissue health, making the blend both effective and well-tolerated.
Apply the cream once daily to clean, dry skin on the inner thigh, forearm, or abdomen. Rotate application sites and avoid skin-to-skin contact until fully absorbed. If your uterus is intact, your clinician will recommend pairing Bi-Est with progesterone for balance and safety.
Many women begin to feel improvements in hot flashes, sleep, or mood within one to two weeks after using Bi-Est 50/50 cream. Full benefits—including more consistent symptom relief and improved skin or vaginal tissue health—often develop over three months of consistent use
Mild breast tenderness or spotting may occur as hormone levels adjust. Less common effects include headaches or nausea. To prevent estrogen dominance symptoms, therapy should remain balanced with progesterone and monitored by your clinician.
The medication includes an initial consultation with a licensed clinician, a free baseline hormone lab, a personalized treatment plan, regular check-ins to track progress, plus the Bi-Est 50/50 Cream. We offer HRT in 3-month treatment cycles to ensure safe, effective dose adjustments and proper clinical monitoring. The 3 month cost for Bi-Est 50/50 Cream is $239 which is equivalent to $80/month. If you are ineligible for treatment, you will be refunded the cost of the medication. Follow up labs may be necessary as part of your care plan and are charged separately.
