My experience with Healthspan has been pivotal because everyone listens and wants to help…and being on HRT has changed my life.
Bi-Est 50/50 Cream
Topical cream combining two bio-identical estrogens, Estradiol and Estriol, delivered through the skin. HRT medications are accessed through Membership, which includes labs and ongoing clinical care for safe prescribing and treatment.
Replenishes estrogen levels to help reduce hot flashes, night sweats, and dryness while improving tissue elasticity.
Balances neurotransmitters and cortisol to ease anxiety, sharpen focus, and improve sleep quality.
Helps prevent bone loss while maintaining cardiovascular, metabolic and brain health over time.
benefits
Your symptoms start with biology. So does relief.
Stabilizes mood and temperature control while easing hot flashes and night sweats.
Restores hydration, elasticity, and circulation in skin and vaginal tissues.
Promotes healthy metabolism, vascular tone, and long-term heart health.
your complete care
Personalized HRT care starts with membership
Your health is personal, and so is our approach. We use the latest science and data-driven insights to design care built around you.
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Effective treatments and excellent service earns us loyal support.
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+
avg. yrs of experience
The MDs and PhDs on our clinical and research teams are experts.
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K
biomarkers analyzed
We use insights from labs to personalize care and track progress.
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Clinician-guided HRT treatment
Clinician-guided bioidentical HRT for symptom relief and long-term health.
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Frequently asked questions
Bi-Est 50/50 is a bio-identical estrogen cream containing a balanced blend of estradiol (E2) and estriol (E3). It’s designed to relieve menopause-related symptoms such as hot flashes, night sweats, mood changes, and vaginal dryness while supporting overall hormonal balance.
This compounded cream delivers estrogen directly through the skin, allowing for steady absorption and symptom relief. Estradiol provides stronger estrogenic activity, while estriol offers gentler support for vaginal and skin tissue health, making the blend both effective and well-tolerated.
Apply the cream once daily to clean, dry skin on the inner thigh, forearm, or abdomen. Rotate application sites and avoid skin-to-skin contact until fully absorbed. If your uterus is intact, your clinician will recommend pairing Bi-Est with progesterone for balance and safety.
A baseline lab gives your clinical team the biological information needed to prescribe hormones responsibly and personalize your protocol from the start. Because hormones influence multiple systems in the body, symptoms alone don’t provide enough clarity to determine the most appropriate treatment approach.
Many women begin to feel improvements in hot flashes, sleep, or mood within one to two weeks after using Bi-Est 50/50 cream. Full benefits—including more consistent symptom relief and improved skin or vaginal tissue health—often develop over three months of consistent use
Mild breast tenderness or spotting may occur as hormone levels adjust. Less common effects include headaches or nausea. To prevent estrogen dominance symptoms, therapy should remain balanced with progesterone and monitored by your clinician.
Bi-Est 50/50 Cream requires ongoing clinical oversight to be prescribed safely and effectively. At Healthspan, HRT medications are delivered through membership because hormone levels, symptoms, and side effects change over time and need active monitoring. Membership includes baseline and follow-up lab testing, clinician review, and ongoing support to ensure dosing remains within safe ranges, treatment stays effective, and potential risks are identified early. This care model is designed to support long-term health outcomes, not one-time prescribing.
Bi-Est 50/50 Cream through Healthspan includes two components: membership and medication. The cream is priced at $80 per month, and Healthspan members receive a discounted rate of $64 per month. When billed quarterly, the cost is $192, marked down from $240. Membership covers the clinical care required for safe and effective treatment, including lab testing, clinician review, and ongoing support. Medication is billed separately and only when prescribed.
Bi-Est 50/50 is a bio-identical estrogen cream containing a balanced blend of estradiol (E2) and estriol (E3). It’s designed to relieve menopause-related symptoms such as hot flashes, night sweats, mood changes, and vaginal dryness while supporting overall hormonal balance.
This compounded cream delivers estrogen directly through the skin, allowing for steady absorption and symptom relief. Estradiol provides stronger estrogenic activity, while estriol offers gentler support for vaginal and skin tissue health, making the blend both effective and well-tolerated.
Apply the cream once daily to clean, dry skin on the inner thigh, forearm, or abdomen. Rotate application sites and avoid skin-to-skin contact until fully absorbed. If your uterus is intact, your clinician will recommend pairing Bi-Est with progesterone for balance and safety.
A baseline lab gives your clinical team the biological information needed to prescribe hormones responsibly and personalize your protocol from the start. Because hormones influence multiple systems in the body, symptoms alone don’t provide enough clarity to determine the most appropriate treatment approach.
Many women begin to feel improvements in hot flashes, sleep, or mood within one to two weeks after using Bi-Est 50/50 cream. Full benefits—including more consistent symptom relief and improved skin or vaginal tissue health—often develop over three months of consistent use
Mild breast tenderness or spotting may occur as hormone levels adjust. Less common effects include headaches or nausea. To prevent estrogen dominance symptoms, therapy should remain balanced with progesterone and monitored by your clinician.
Bi-Est 50/50 Cream requires ongoing clinical oversight to be prescribed safely and effectively. At Healthspan, HRT medications are delivered through membership because hormone levels, symptoms, and side effects change over time and need active monitoring. Membership includes baseline and follow-up lab testing, clinician review, and ongoing support to ensure dosing remains within safe ranges, treatment stays effective, and potential risks are identified early. This care model is designed to support long-term health outcomes, not one-time prescribing.
Bi-Est 50/50 Cream through Healthspan includes two components: membership and medication. The cream is priced at $80 per month, and Healthspan members receive a discounted rate of $64 per month. When billed quarterly, the cost is $192, marked down from $240. Membership covers the clinical care required for safe and effective treatment, including lab testing, clinician review, and ongoing support. Medication is billed separately and only when prescribed.
