Treatments
Personalized Protocols
Labs
Medications
Supplements
Optimization
Labs
Coaching
Personalized Protocols
Goals
Optimize longevity
Fat loss
Target joint pain
Grow stronger, healthier hair
Boost energy
Get healthier skin
About
Our Company
Our Mission
How it Works
Read our latest research
Suppressing Two Signals of Aging: Insights from the 2025 Rapamycin–Trametinib Study
Targeting mTOR with Rapamycin Across Species: How Hypertrophic Cardiomyopathy Reversal in Cats Informs Human Cardiac Aging and Longevity
The Biology of Cold Exposure: A Hormetic Stressor That Activates Autophagy, Improves Metabolism, and Reduces Inflammation—But Only If You Shiver
Research
Log in
Get Started
Menu
Treatments
Optimization
Goals
About
Research
Log in
Get started
All studies
(autophagy)
Longevity
07 / 04 / 2025
•
11 MIN READ
The Biology of Cold Exposure: A Hormetic Stressor That Activates Autophagy, Improves Metabolism, and Reduces Inflammation—But Only If You Shiver
Metabolism
04 / 26 / 2025
•
14 MIN READ
Pharmacological Fasting: How SGLT-2 Inhibitors Emulate Caloric Restriction to Target Key Longevity Pathways
Longevity
12 / 07 / 2024
•
25 MIN READ
Two Waves of Aging: How Midlife Biomolecular Shifts Accelerate Decline
Brain
10 / 19 / 2024
•
19 MIN READ
The Role of the Glymphatic System and Autophagy in Neurodegenerative Disease Prevention
Longevity
06 / 22 / 2024
•
35 MIN READ
Regulating Anabolic and Catabolic Signaling for Healthspan Optimization: Impacts of Rapamycin, Exercise, and Testosterone Replacement Therapy
Longevity
11 / 16 / 2023
•
11 MIN READ
Taming Aging With Metformin: How A Diabetes Medication Can Change The Way We Age
Longevity
04 / 22 / 2023
•
20 MIN READ
The Paradox of Senescence: The Interplay Between Rapamycin, Autophagy, and Aging
Longevity
06 / 11 / 2022
•
11 MIN READ
Clearing out the Cellular Trash: The Importance of Mitophagy in the Removal of Damaged & Dysfunctional Mitochondria