AMPK Blend
Activates AMPK—the body's master energy regulator—to improve insulin sensitivity, increase fat oxidation, and enhance mitochondrial energy production. Designed to support metabolic health, regulate blood sugar, and promote sustained energy and cellular resilience.
Supports healthy mitochondria to increase steady, all-day energy without stimulants.
Helps improve glucose control and reduce energy dips tied to insulin spikes.
Promotes fat-burning for cleaner, longer-lasting fuel throughout the day.
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Unlock the science of metabolic activation
longevity pathways
To affect longevity, we must understand its pathways
AMPK
AMPK monitors cellular energy levels and when activated by dihydroberberine or green tea polyphenols, prompts cells to increase glucose uptake and fatty acid oxidation, improving metabolic stability and slowing age-related cellular decline.
Mitochondrial Biogenesis
AMPK activation upregulates PGC-1α to drive mitochondrial formation and maintenance. Increasing mitochondrial quantity and quality generates more ATP, reducing fatigue and oxidative stress for healthier aging.
mTOR Pathway Modulation
AMPK counterbalances excessive mTOR activity by nudging cells out of constant growth mode, allowing critical maintenance and repair to occur while preserving cellular integrity.
Insulin/IGF-1 Signaling
AMPK enhances insulin sensitivity by promoting glucose transporter movement to cell surfaces, lowering circulating glucose and insulin levels to reduce pancreatic stress and improve metabolic health.
Lipid Metabolism
AMPK boosts fatty acid oxidation, pushing cells to utilize stored fats for energy. This leads to balanced triglyceride and cholesterol levels, benefiting cardiovascular health and reducing lipid-driven tissue damage.
Inflammatory & Oxidative Stress
AMPK downregulates pro-inflammatory pathways like NF-κB while complementary polyphenols provide antioxidants that reduce reactive oxygen species, maintaining tissue function and slowing age-related inflammation.
Fasting-Mimetic Mechanisms
AMPK ingredients mimic caloric restriction's metabolic adjustments, prompting efficient energy store usage. This partial fasting effect supports healthy aging without requiring strict dietary limitations.
Metabolic Flexibility & Adaptation
AMPK enables seamless switching between carbohydrate and fat fuels, supporting weight management, improving stress resilience, and diminishing cellular damage that contributes to accelerated aging.
AMPK
AMPK monitors cellular energy levels and when activated by dihydroberberine or green tea polyphenols, prompts cells to increase glucose uptake and fatty acid oxidation, improving metabolic stability and slowing age-related cellular decline.
Mitochondrial Biogenesis
AMPK activation upregulates PGC-1α to drive mitochondrial formation and maintenance. Increasing mitochondrial quantity and quality generates more ATP, reducing fatigue and oxidative stress for healthier aging.
mTOR Pathway Modulation
AMPK counterbalances excessive mTOR activity by nudging cells out of constant growth mode, allowing critical maintenance and repair to occur while preserving cellular integrity.
Insulin/IGF-1 Signaling
AMPK enhances insulin sensitivity by promoting glucose transporter movement to cell surfaces, lowering circulating glucose and insulin levels to reduce pancreatic stress and improve metabolic health.
Lipid Metabolism
AMPK boosts fatty acid oxidation, pushing cells to utilize stored fats for energy. This leads to balanced triglyceride and cholesterol levels, benefiting cardiovascular health and reducing lipid-driven tissue damage.
Inflammatory & Oxidative Stress
AMPK downregulates pro-inflammatory pathways like NF-κB while complementary polyphenols provide antioxidants that reduce reactive oxygen species, maintaining tissue function and slowing age-related inflammation.
Fasting-Mimetic Mechanisms
AMPK ingredients mimic caloric restriction's metabolic adjustments, prompting efficient energy store usage. This partial fasting effect supports healthy aging without requiring strict dietary limitations.
Metabolic Flexibility & Adaptation
AMPK enables seamless switching between carbohydrate and fat fuels, supporting weight management, improving stress resilience, and diminishing cellular damage that contributes to accelerated aging.
AMPK
AMPK monitors cellular energy levels and when activated by dihydroberberine or green tea polyphenols, prompts cells to increase glucose uptake and fatty acid oxidation, improving metabolic stability and slowing age-related cellular decline.
Mitochondrial Biogenesis
AMPK activation upregulates PGC-1α to drive mitochondrial formation and maintenance. Increasing mitochondrial quantity and quality generates more ATP, reducing fatigue and oxidative stress for healthier aging.
mTOR Pathway Modulation
AMPK counterbalances excessive mTOR activity by nudging cells out of constant growth mode, allowing critical maintenance and repair to occur while preserving cellular integrity.
Insulin/IGF-1 Signaling
AMPK enhances insulin sensitivity by promoting glucose transporter movement to cell surfaces, lowering circulating glucose and insulin levels to reduce pancreatic stress and improve metabolic health.
Lipid Metabolism
AMPK boosts fatty acid oxidation, pushing cells to utilize stored fats for energy. This leads to balanced triglyceride and cholesterol levels, benefiting cardiovascular health and reducing lipid-driven tissue damage.
Inflammatory & Oxidative Stress
AMPK downregulates pro-inflammatory pathways like NF-κB while complementary polyphenols provide antioxidants that reduce reactive oxygen species, maintaining tissue function and slowing age-related inflammation.
Fasting-Mimetic Mechanisms
AMPK ingredients mimic caloric restriction's metabolic adjustments, prompting efficient energy store usage. This partial fasting effect supports healthy aging without requiring strict dietary limitations.
Metabolic Flexibility & Adaptation
AMPK enables seamless switching between carbohydrate and fat fuels, supporting weight management, improving stress resilience, and diminishing cellular damage that contributes to accelerated aging.
AMPK
AMPK monitors cellular energy levels and when activated by dihydroberberine or green tea polyphenols, prompts cells to increase glucose uptake and fatty acid oxidation, improving metabolic stability and slowing age-related cellular decline.
Mitochondrial Biogenesis
AMPK activation upregulates PGC-1α to drive mitochondrial formation and maintenance. Increasing mitochondrial quantity and quality generates more ATP, reducing fatigue and oxidative stress for healthier aging.
mTOR Pathway Modulation
AMPK counterbalances excessive mTOR activity by nudging cells out of constant growth mode, allowing critical maintenance and repair to occur while preserving cellular integrity.
Insulin/IGF-1 Signaling
AMPK enhances insulin sensitivity by promoting glucose transporter movement to cell surfaces, lowering circulating glucose and insulin levels to reduce pancreatic stress and improve metabolic health.
Lipid Metabolism
AMPK boosts fatty acid oxidation, pushing cells to utilize stored fats for energy. This leads to balanced triglyceride and cholesterol levels, benefiting cardiovascular health and reducing lipid-driven tissue damage.
Inflammatory & Oxidative Stress
AMPK downregulates pro-inflammatory pathways like NF-κB while complementary polyphenols provide antioxidants that reduce reactive oxygen species, maintaining tissue function and slowing age-related inflammation.
Fasting-Mimetic Mechanisms
AMPK ingredients mimic caloric restriction's metabolic adjustments, prompting efficient energy store usage. This partial fasting effect supports healthy aging without requiring strict dietary limitations.
Metabolic Flexibility & Adaptation
AMPK enables seamless switching between carbohydrate and fat fuels, supporting weight management, improving stress resilience, and diminishing cellular damage that contributes to accelerated aging.
A highly bioavailable derivative of berberine, it activates AMPK to improve glucose uptake, insulin sensitivity, and lipid metabolism more efficiently than standard berberine.
A bioactive compound derived from ginger, it activates AMPK and promotes fat oxidation, thermogenesis, and glycemic control while providing anti-inflammatory support.
A metabolite of curcumin with potent antioxidant and anti-inflammatory activity, it supports mitochondrial function and helps reduce systemic inflammation—an AMPK-activating signal.
A highly absorbable form of silybin, it supports liver detoxification and may reduce lipid accumulation in the liver, while also offering antioxidant protection.
A naturally occurring compound produced by gut bacteria from the metabolism of ellagic acid and ellagitannins, found in foods like pomegranates and berries. Studies indicate Urolitin A has the potential to improve mitochondrial health, muscle strength, and other anti-aging effects.
Rich in EGCG and formulated for enhanced absorption, this supports AMPK activation, reduces oxidative stress, and promotes fat oxidation and mitochondrial biogenesis.
A patented fulvic acid-mineral complex that supports mitochondrial enzyme function, cellular energy production, and nutrient absorption. It may enhance AMPK-related mitochondrial efficiency and redox balance.
Included with AMPK Blend
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Frequently asked questions
A clinical supplement blend that activates AMPK to improve metabolic flexibility, fat oxidation, and glucose regulation. It's designed to support long-term energy production, better glucose control, and mitochondrial function.
Yes. It can be used independently or paired with protocols like Rapamycin, Metformin, or Autophagy Blend for synergistic benefits.
People often notice better energy and stamina in 1–2 weeks. Blood sugar, insulin, and lipid improvements typically become noticeable within 4–12 weeks of consistent use.
No fasting is required, but a whole-food, nutrient-dense diet or intermittent fasting may enhance metabolic outcomes and cellular responses.
Yes. AMPK activation can complement pharmaceutical agents like metformin or SGLT2 inhibitors. However, it’s best to consult your provider when combining with prescription medications.
Tracking markers like fasting glucose, HOMA-IR, triglycerides, hs-CRP, and subjective energy can help assess progress and guide optimization.
Yes. The ingredients are non-stimulant and well-tolerated. It can be cycled or used long-term as part of a preventive health strategy.
Just resume your protocol as soon as possible. Small gaps won’t negate long-term results—consistency over weeks and months matters more.
Yes. It supports metabolic energy without caffeine or stimulants, making it suitable for sensitive users and long-term use.
A clinical supplement blend that activates AMPK to improve metabolic flexibility, fat oxidation, and glucose regulation. It's designed to support long-term energy production, better glucose control, and mitochondrial function.
Yes. It can be used independently or paired with protocols like Rapamycin, Metformin, or Autophagy Blend for synergistic benefits.
People often notice better energy and stamina in 1–2 weeks. Blood sugar, insulin, and lipid improvements typically become noticeable within 4–12 weeks of consistent use.
No fasting is required, but a whole-food, nutrient-dense diet or intermittent fasting may enhance metabolic outcomes and cellular responses.
Yes. AMPK activation can complement pharmaceutical agents like metformin or SGLT2 inhibitors. However, it’s best to consult your provider when combining with prescription medications.
Tracking markers like fasting glucose, HOMA-IR, triglycerides, hs-CRP, and subjective energy can help assess progress and guide optimization.
Yes. The ingredients are non-stimulant and well-tolerated. It can be cycled or used long-term as part of a preventive health strategy.
Just resume your protocol as soon as possible. Small gaps won’t negate long-term results—consistency over weeks and months matters more.
Yes. It supports metabolic energy without caffeine or stimulants, making it suitable for sensitive users and long-term use.
Reviews
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