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Suppressing Two Signals of Aging: Insights from the 2025 Rapamycin–Trametinib Study
Targeting mTOR with Rapamycin Across Species: How Hypertrophic Cardiomyopathy Reversal in Cats Informs Human Cardiac Aging and Longevity
The Biology of Cold Exposure: A Hormetic Stressor That Activates Autophagy, Improves Metabolism, and Reduces Inflammation—But Only If You Shiver
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All studies
(hyperfunction)
Brain
02 / 08 / 2025
•
19 MIN READ
Alzheimer’s Disease as Type 3 Diabetes: Evidence for Insulin Resistance and Metabolic Dysfunction as Drivers of AD Pathogenesis
Longevity
12 / 07 / 2024
•
25 MIN READ
Two Waves of Aging: How Midlife Biomolecular Shifts Accelerate Decline
Longevity
06 / 22 / 2024
•
35 MIN READ
Regulating Anabolic and Catabolic Signaling for Healthspan Optimization: Impacts of Rapamycin, Exercise, and Testosterone Replacement Therapy
Longevity
03 / 23 / 2024
•
29 MIN READ
Autophagy, Cellular Senescence, and the Promise of Topical Rapamycin in Hair Regeneration
Longevity
04 / 08 / 2023
•
8 MIN READ
Rapamycin's Role as a Molecular Brake for Cellular Hyperfunction and Runaway Cells
Longevity
09 / 27 / 2022
•
14 MIN READ
Cell senescence, Rapamycin and Hyperfunction Theory of Aging
hyperfunction | Healthspan