Urolithin A

Urolithin A clears out damaged mitochondria and restores your body’s energy from the inside out—supporting endurance, recovery, and long-term vitality.

Supports natural energy by helping cells work more efficiently.

Reduces post-activity fatigue and helps muscles feel stronger, faster.

Promotes better cellular repair to keep you active as you age.

HSA/FSA Eligible

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Improves cellular energy and muscle strength to promote better endurance and support healthy aging.

Urolithin A

Your transformation timeline begins with the first month

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Benefits

Flex your cellular health

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Energizing
Renewing
Strengthening
(01)
Build Cellular EnergyUrolithin A restores energy production by enhancing mitochondrial function, helping you power through daily tasks with less fatigue.
(02)
Support Healthy AgingActivates longevity pathways like mitophagy and AMPK, which help the body clear cellular waste and stay resilient over time.
(03)
Strengthen Muscle PerformanceSupports muscle health by improving endurance, reducing post-activity soreness, and making it easier to sustain physical effort as you age.
Follow The Science

Mitophagy Activation

Urolithin A supports mitophagy, your body’s way of removing old, dysfunctional mitochondria—helping cells run more efficiently.

Activates AMPK Pathways

By activating AMPK, Urolithin A helps your body burn fat, manage blood sugar, and produce clean cellular energy.

Modulates mTOR for Renewal

Urolithin A gently slows mTOR activity—encouraging cellular renewal and better stress recovery.

Reduce Chronic Inflammation

Gut-driven SCFAs suppress systemic inflammation, supporting cardiovascular, cognitive, and metabolic resilience.

Mimic Caloric Restriction without 
Fasting

By reducing carbohydrate availability, Acarbose acts as a calorie restriction mimetic—impacting IGF-1, insulin signaling, and mitochondrial health.

becoming a patient

Your journey to a longer, healthier life is just a few steps away

How It Works

Included with Urolithin A

Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.

Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.

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Urolithin A
Support cellular energy renewalStarting at $65/month
Your Protocol

Hear from our patients

Impressive organization!

The doctors and the way your programs and labs and med delivery are top notch, very professional and the accessibility of the doctors and different programs available along with the text and emails explaining the benefits and what’s new out there are all.

Jernigan Transport

Great experience with Healthspan

I’ve had a great experience with Healthspan. All of the representatives have been extremely responsive when sending messages on the portal, and I had a great call reviewing my initial labs with Brandon Fell.

Anthony Badillo

Grateful for Healthspan

The most knowledgeable team. Helped me evaluate my labs and put together a plan to start optimizing things. I wish my current doctors were this thorough.

DANNY

Reviews

5/5

124 reviews

blanchards

Healthspan is amazing!!!

Kristen was fantastic …she was kind, informative and professional. She helped me in my journey to Health and longevity! Thank you!!

Jim White

Healthspan continues to be cutting edge

Healthspan continues to be cutting edge with regard to health and longevity. Brandon was knowledgeable and supportive. The details of the study were explained well and in detail.

Anthony Badillo

Great experience with Healthspan

I’ve had a great experience with Healthspan. All of the representatives have been extremely responsive when sending messages on the portal, and I had a great call reviewing my initial labs with Brandon Fell who was extremely knowledgeable and courteous. I’ve started the Rapamycin and Acarbose protocol, and I’m looking forward to seeing what my updated labs will show in a couple months!

Frequently asked questions

What is Urolithin A?

Urolithin A is a compound derived from the gut microbiota’s transformation of ellagitannins, which are found in foods like pomegranates, walnuts, and berries. It is renowned for its ability to enhance mitochondrial function and support longevity.

How does Healthspan dose Urolithin A?

Healthspan recommends starting with 500 mg of Urolithin A daily, taken with meals. Depending on individual response and health goals, the dose can be increased to 1,000 mg.

How does Urolithin A work in the body?

Urolithin A promotes mitophagy, the selective removal of damaged mitochondria. This process helps improve mitochondrial efficiency, leading to better energy production, enhanced muscle endurance, and improved metabolic health.

What conditions may benefit from Urolithin A?

Urolithin A can benefit individuals looking to improve muscle endurance, maintain cognitive health, enhance cardiovascular function, and prevent metabolic disorders like diabetes. It is also widely used for its anti-aging properties.

What are the potential side effects of Urolithin A?

Urolithin A is well-tolerated by most individuals, though mild digestive discomfort such as bloating or nausea can occur at higher doses. Taking it with food can help minimize these effects.

How long does it take for Urolithin A to work?

While results may vary, most individuals experience improvements in muscle endurance and energy levels within 4-8 weeks. Long-term benefits for metabolic health and aging typically emerge after 12 weeks of consistent use.

Can I take Urolithin A with other supplements and medications?

It is recommended to consult with a healthcare provider before combining Urolithin A with other medications, particularly those that affect mitochondrial function or energy metabolism, such as metformin.

Can I take Urolithin A with my other Healthspan protocols and supplements?

Yes, Urolithin A can be integrated with other Healthspan protocols, particularly those aimed at improving energy metabolism, muscle health, and longevity.

Is Urolithin A FDA-approved?

Urolithin A is not FDA-approved for any specific medical treatments. However, it has been granted Generally Recognized As Safe (GRAS) status by the FDA for use as a dietary supplement, particularly for its role in supporting mitochondrial health, enhancing muscle function, and promoting longevity. This designation indicates that Urolithin A is considered safe when used according to recommended guidelines.

What is Urolithin A?

Urolithin A is a compound derived from the gut microbiota’s transformation of ellagitannins, which are found in foods like pomegranates, walnuts, and berries. It is renowned for its ability to enhance mitochondrial function and support longevity.

How does Healthspan dose Urolithin A?

Healthspan recommends starting with 500 mg of Urolithin A daily, taken with meals. Depending on individual response and health goals, the dose can be increased to 1,000 mg.

How does Urolithin A work in the body?

Urolithin A promotes mitophagy, the selective removal of damaged mitochondria. This process helps improve mitochondrial efficiency, leading to better energy production, enhanced muscle endurance, and improved metabolic health.

What conditions may benefit from Urolithin A?

Urolithin A can benefit individuals looking to improve muscle endurance, maintain cognitive health, enhance cardiovascular function, and prevent metabolic disorders like diabetes. It is also widely used for its anti-aging properties.

What are the potential side effects of Urolithin A?

Urolithin A is well-tolerated by most individuals, though mild digestive discomfort such as bloating or nausea can occur at higher doses. Taking it with food can help minimize these effects.

How long does it take for Urolithin A to work?

While results may vary, most individuals experience improvements in muscle endurance and energy levels within 4-8 weeks. Long-term benefits for metabolic health and aging typically emerge after 12 weeks of consistent use.

Can I take Urolithin A with other supplements and medications?

It is recommended to consult with a healthcare provider before combining Urolithin A with other medications, particularly those that affect mitochondrial function or energy metabolism, such as metformin.

Can I take Urolithin A with my other Healthspan protocols and supplements?

Yes, Urolithin A can be integrated with other Healthspan protocols, particularly those aimed at improving energy metabolism, muscle health, and longevity.

Is Urolithin A FDA-approved?

Urolithin A is not FDA-approved for any specific medical treatments. However, it has been granted Generally Recognized As Safe (GRAS) status by the FDA for use as a dietary supplement, particularly for its role in supporting mitochondrial health, enhancing muscle function, and promoting longevity. This designation indicates that Urolithin A is considered safe when used according to recommended guidelines.