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Suppressing Two Signals of Aging: Insights from the 2025 Rapamycin–Trametinib Study
Targeting mTOR with Rapamycin Across Species: How Hypertrophic Cardiomyopathy Reversal in Cats Informs Human Cardiac Aging and Longevity
The Biology of Cold Exposure: A Hormetic Stressor That Activates Autophagy, Improves Metabolism, and Reduces Inflammation—But Only If You Shiver
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(sglt2)
Longevity
06 / 21 / 2025
•
29 MIN READ
The Case for Cyclical Longevity Protocols: How Rhythmic Activation of AMPK and Autophagy Reprograms Aging Cells
Brain
06 / 07 / 2025
•
20 MIN READ
The Energy Equation in Alzheimer’s Disease: Glucose-Driven Degeneration and Ketone-Driven Protection
Longevity
05 / 30 / 2025
•
32 MIN READ
The Mitochondrial Signature of Long COVID: What PRDX3 Is Trying to Tell Us—And How We Might Reverse It
Metabolism
04 / 26 / 2025
•
14 MIN READ
Pharmacological Fasting: How SGLT-2 Inhibitors Emulate Caloric Restriction to Target Key Longevity Pathways
Metabolism
03 / 08 / 2025
•
28 MIN READ
SGLT2 Inhibitors as Metabolic Senolytics: Clearing Senescent Cells to Combat Pathological Aging
Metabolism
01 / 25 / 2025
•
21 MIN READ
Mitochondria’s Paradoxical Role in Cancer Biology: Exploiting Metabolic Vulnerabilities for Therapeutic Targeting
Metabolism
01 / 18 / 2025
•
28 MIN READ
SGLT-2 Inhibitors in Aging and Healthspan: Surprising Mechanistic Insights Into Adipose Tissue Reduction, Lean Mass Preservation, and Longevity
sglt2 | Healthspan