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Suppressing Two Signals of Aging: Insights from the 2025 Rapamycin–Trametinib Study
Targeting mTOR with Rapamycin Across Species: How Hypertrophic Cardiomyopathy Reversal in Cats Informs Human Cardiac Aging and Longevity
The Biology of Cold Exposure: A Hormetic Stressor That Activates Autophagy, Improves Metabolism, and Reduces Inflammation—But Only If You Shiver
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All studies
(Exercise)
Metabolism
04 / 18 / 2025
•
17 MIN READ
The Surprising Role of Abdominal Subcutaneous Fat as a Metabolic Buffer—And How Endurance Training Re‑Programs It
Metabolism
02 / 28 / 2025
•
23 MIN READ
Reevaluating Midlife Metabolic Decline: A Four-Factor Framework Integrating Muscle, Mitochondrial Function, Hormones, and Inflammation
Metabolism
01 / 25 / 2025
•
21 MIN READ
Mitochondria’s Paradoxical Role in Cancer Biology: Exploiting Metabolic Vulnerabilities for Therapeutic Targeting
Metabolism
01 / 18 / 2025
•
28 MIN READ
SGLT-2 Inhibitors in Aging and Healthspan: Surprising Mechanistic Insights Into Adipose Tissue Reduction, Lean Mass Preservation, and Longevity
Lifestyle
11 / 02 / 2024
•
14 MIN READ
The Crucial Role of Inflammation in Exercise-Induced Reduction of Cellular Senescence
Brain
10 / 19 / 2024
•
19 MIN READ
The Role of the Glymphatic System and Autophagy in Neurodegenerative Disease Prevention
Lifestyle
08 / 30 / 2024
•
43 MIN READ
Mitochondrial and Metabolic Disparities Between Sedentary and Active Individuals: A Comparative Analysis at Rest and During Exercise
Lifestyle
08 / 30 / 2024
•
43 MIN READ
Mitochondrial and Metabolic Differences Between Sedentary and Active Individuals at Rest and During Exercise: The Hidden Costs of Inactivity
Metabolism
08 / 24 / 2024
•
29 MIN READ
Brown and Beige Fat's Role in Optimizing Metabolic Function
Metabolism
08 / 10 / 2024
•
35 MIN READ
Optimizing Glucose Metabolism: The Role of Exercise Modalities and Dietary Interventions
Longevity
06 / 22 / 2024
•
35 MIN READ
Regulating Anabolic and Catabolic Signaling for Healthspan Optimization: Impacts of Rapamycin, Exercise, and Testosterone Replacement Therapy
Lifestyle
06 / 15 / 2024
•
11 MIN READ
The Impact of Zone 2 Endurance Training on Mitochondrial Health and Longevity
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